Since 2008 I am interested in the network analysis, and its application in genome biology. In the summer 2010 I attended the Network Analysis Course given by Dr. Nina Zweig of IWR Uni Heidelberg, which was very inspiring and I would definitely recommend. Interesting topics to me include: - Data Mining approaches to integrate and map biological network data
- Integrate: Software interfaces (e.g. KEGGgraph) and database models
- Map: Integrate advantages of Cytoscape (or Web), yEd and Graphviz to interactively visualize quantitative data in composite networks
- Build correlation graphs (networks) from expression and mutation
- Understand mutant's impact in networks
- Qualitative analysis of networks
- Centrality and its robustness against missing data,
- clustering of directional and weighted network,
- clustering of bipartite graph, and
- network motifs and its functionality in biological networks
- Quantitative modeling of networks
- General Bayesian network
- Boolean network modeling of signaling pathways
- Fuzzy logic network
- Petri network for metabolism networks
Some of my current work is based on the collaboration with Dr. Nina Zweig and Emoke-Agnes Horvath. In addition I am collaborating with Dr. Dennis Thieffry in Paris. The aim is to translate knowledge from network analysis into drug targeting and clinical practices. |